O:9:"MagpieRSS":24:{s:6:"parser";i:0;s:12:"current_item";a:0:{}s:5:"items";a:10:{i:0;a:11:{s:5:"title";s:125:"A star in subtropical Japan: A new species of parasitoid wasp constructs unique cocoon masses hanging on 1-meter-long strings";s:4:"link";s:158:"https://wikileaksisdemocracy.org/a-star-in-subtropical-japan-a-new-species-of-parasitoid-wasp-constructs-unique-cocoon-masses-hanging-on-1-meter-long-strings/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Fri, 03 Dec 2021 23:52:21 +0000";s:8:"category";s:111:"Health And Science1meterlongcocoonconstructshangingJapanmassesparasitoidspeciesStarstringssubtropicaluniquewasp";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=5115";s:11:"description";s:819:"A star in subtropical Japan: A new species of parasitoid wasp constructs unique cocoon masses hanging on 1-meter-long strings ? NovLink Home Mash P A star in subtropical Japan: A new species of parasitoid wasp constructs unique cocoon masses hanging on 1-meter-long strings We would like to thank the writer of this short article for ... Read more";s:7:"content";a:1:{s:7:"encoded";s:6874:"
A star in subtropical Japan: A new species of parasitoid wasp constructs unique cocoon masses hanging on 1-meter-long strings ? NovLink
We would like to thank the writer of this short article for this outstanding content
";}s:7:"summary";s:819:"A star in subtropical Japan: A new species of parasitoid wasp constructs unique cocoon masses hanging on 1-meter-long strings ? NovLink Home Mash P A star in subtropical Japan: A new species of parasitoid wasp constructs unique cocoon masses hanging on 1-meter-long strings We would like to thank the writer of this short article for ... Read more";s:12:"atom_content";s:6874:"
A star in subtropical Japan: A new species of parasitoid wasp constructs unique cocoon masses hanging on 1-meter-long strings ? NovLink
We would like to thank the writer of this short article for this outstanding content
";s:14:"date_timestamp";i:1638575541;}i:1;a:11:{s:5:"title";s:52:"Another reason why batteries can?t charge in minutes";s:4:"link";s:85:"https://wikileaksisdemocracy.org/another-reason-why-batteries-cant-charge-in-minutes/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Fri, 03 Dec 2021 22:35:05 +0000";s:8:"category";s:46:"Health And Sciencebatterieschargeminutesreason";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=5110";s:11:"description";s:674:"Journal Reference: Saran Pidaparthy, Marco-Tulio F. Rodrigues, Jian-Min Zuo, Daniel P. Abraham. Increased Disorder at Graphite Particle Edges Revealed by Multi-length Scale Characterization of Anodes from Fast-Charged Lithium-Ion Cells. Journal of The Electrochemical Society, 2021; 168 (10): 100509 DOI: 10.1149/1945-7111/ac2a7f Haste makes waste, as the saying goes. Such a maxim may be especially true of ... Read more";s:7:"content";a:1:{s:7:"encoded";s:3782:"
Journal Reference:
Saran Pidaparthy, Marco-Tulio F. Rodrigues, Jian-Min Zuo, Daniel P. Abraham. Increased Disorder at Graphite Particle Edges Revealed by Multi-length Scale Characterization of Anodes from Fast-Charged Lithium-Ion Cells. Journal of The Electrochemical Society, 2021; 168 (10): 100509 DOI: 10.1149/1945-7111/ac2a7f
Haste makes waste, as the saying goes. Such a maxim may be especially true of batteries, thanks to a new study that seeks to identify the reasons that cause the performance of fast charged lithium-ion batteries to degrade in electric vehicles.
In new research from the U.S. Department of Energy?s (DOE) Argonne National Laboratory, scientists have found interesting chemical behavior of one of the battery?s two terminals as the battery is charged and discharged.
Lithium-ion batteries contain both a positively charged cathode and a negatively charged anode, which are separated by a material called an electrolyte that moves lithium ions between them. The anode in these batteries is typically made out of graphite ? the same material found in many pencils. In lithium-ion batteries, however, the graphite is assembled out of small particles. Inside these particles, the lithium ions can insert themselves in a process called intercalation. When intercalation happens properly, the battery can successfully charge and discharge.
When a battery is charged too quickly, however, intercalation becomes a trickier business. Instead of smoothly getting into the graphite, the lithium ions tend to aggregate on top of the anode?s surface, resulting in a ?plating? effect that can cause terminal damage ? no pun intended ? to a battery.
?Plating is one of the main causes of impaired battery performance during fast charging,? said Argonne battery scientist Daniel Abraham, an author of the study. ?As we charged the battery quickly, we found that in addition to the plating on the anode surface there was a build up of reaction products inside the electrode pores.? As a result, the anode itself undergoes some degree of irreversible expansion, impairing battery performance.
Using a technique called scanning electron nanodiffraction, Abraham and his colleagues from the University of Illinois Urbana-Champaign observed another notable change to the graphite particles. At the atomic level, the lattice of graphite atoms at the particle edges becomes distorted because of the repeated fast charging, hindering the intercalation process. ?Basically, what we see is that the atomic network in the graphite becomes warped, and this prevents lithium ions from finding their ?home? inside the particles ? instead, they plate on the particles,? he said.
?The faster we charge our battery, the more atomically disordered the anode will become, which will ultimately prevent the lithium ions from being able to move back and forth,? Abraham said. ?The key is to find ways to either prevent this loss of organization or to somehow modify the graphite particles so that the lithium ions can intercalate more efficiently.?
We want to thank the author of this post for this awesome material
";}s:7:"summary";s:674:"Journal Reference: Saran Pidaparthy, Marco-Tulio F. Rodrigues, Jian-Min Zuo, Daniel P. Abraham. Increased Disorder at Graphite Particle Edges Revealed by Multi-length Scale Characterization of Anodes from Fast-Charged Lithium-Ion Cells. Journal of The Electrochemical Society, 2021; 168 (10): 100509 DOI: 10.1149/1945-7111/ac2a7f Haste makes waste, as the saying goes. Such a maxim may be especially true of ... Read more";s:12:"atom_content";s:3782:"
Journal Reference:
Saran Pidaparthy, Marco-Tulio F. Rodrigues, Jian-Min Zuo, Daniel P. Abraham. Increased Disorder at Graphite Particle Edges Revealed by Multi-length Scale Characterization of Anodes from Fast-Charged Lithium-Ion Cells. Journal of The Electrochemical Society, 2021; 168 (10): 100509 DOI: 10.1149/1945-7111/ac2a7f
Haste makes waste, as the saying goes. Such a maxim may be especially true of batteries, thanks to a new study that seeks to identify the reasons that cause the performance of fast charged lithium-ion batteries to degrade in electric vehicles.
In new research from the U.S. Department of Energy?s (DOE) Argonne National Laboratory, scientists have found interesting chemical behavior of one of the battery?s two terminals as the battery is charged and discharged.
Lithium-ion batteries contain both a positively charged cathode and a negatively charged anode, which are separated by a material called an electrolyte that moves lithium ions between them. The anode in these batteries is typically made out of graphite ? the same material found in many pencils. In lithium-ion batteries, however, the graphite is assembled out of small particles. Inside these particles, the lithium ions can insert themselves in a process called intercalation. When intercalation happens properly, the battery can successfully charge and discharge.
When a battery is charged too quickly, however, intercalation becomes a trickier business. Instead of smoothly getting into the graphite, the lithium ions tend to aggregate on top of the anode?s surface, resulting in a ?plating? effect that can cause terminal damage ? no pun intended ? to a battery.
?Plating is one of the main causes of impaired battery performance during fast charging,? said Argonne battery scientist Daniel Abraham, an author of the study. ?As we charged the battery quickly, we found that in addition to the plating on the anode surface there was a build up of reaction products inside the electrode pores.? As a result, the anode itself undergoes some degree of irreversible expansion, impairing battery performance.
Using a technique called scanning electron nanodiffraction, Abraham and his colleagues from the University of Illinois Urbana-Champaign observed another notable change to the graphite particles. At the atomic level, the lattice of graphite atoms at the particle edges becomes distorted because of the repeated fast charging, hindering the intercalation process. ?Basically, what we see is that the atomic network in the graphite becomes warped, and this prevents lithium ions from finding their ?home? inside the particles ? instead, they plate on the particles,? he said.
?The faster we charge our battery, the more atomically disordered the anode will become, which will ultimately prevent the lithium ions from being able to move back and forth,? Abraham said. ?The key is to find ways to either prevent this loss of organization or to somehow modify the graphite particles so that the lithium ions can intercalate more efficiently.?
We want to thank the author of this post for this awesome material
";s:14:"date_timestamp";i:1638570905;}i:2;a:11:{s:5:"title";s:79:"For these reasons you CANNOT miss this film with Anthony Hopkins ? Spoiler Time";s:4:"link";s:111:"https://wikileaksisdemocracy.org/for-these-reasons-you-cannot-miss-this-film-with-anthony-hopkins-spoiler-time/";s:2:"dc";a:1:{s:7:"creator";s:12:"Sally Scully";}s:7:"pubdate";s:31:"Fri, 03 Dec 2021 21:23:01 +0000";s:8:"category";s:45:"CelebrityAnthonyfilmHopkinsreasonsSpoilerTime";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=5104";s:11:"description";s:654:"The awards Oscar They are getting closer and closer and it is time to see all the nominees. If you still do not decide to see The Father, the directorial debut of the French playwright Florian Zeller that explores old age and the advances of senile dementia, below we will give you 7 reasons for ... Read more";s:7:"content";a:1:{s:7:"encoded";s:8607:"
The awards Oscar They are getting closer and closer and it is time to see all the nominees. If you still do not decide to see The Father, the directorial debut of the French playwright Florian Zeller that explores old age and the advances of senile dementia, below we will give you 7 reasons for you to do so.
1 Anthony Hopkins
The Father gives us what is, perhaps, the best performance of Anthony Hopkins throughout his career And, the truth is, to say that when we talk about an actor of the caliber of Hopkins, its alot. And yet it is not an exaggeration. Hopkinsmanages to show us the confusion, terror, frustration and pain of this man who begins to lose control of his own mind with great sensitivity and mastery. Truly unmissable and completely deserved his nomination for Best Actor at the awards of the Academia.
Credit: Sony Pictures
2 Senile dementia from another perspective
The wonder of The Father is that, for about two hours, it puts us in the confused mind of Anthony, this man who suffers from senile dementia and, from there, we will perceive reality. It is a different approach, which shakes the viewer with the ups and downs of the memory of Anthony, confusing him and making him empathize with the character.
Source: Sony Pictures
3 Theatrical origin
The Father has its origins in the theater, since the film is an adaptation of the work of the same director, Florian Zeller, which is part of the family trilogy that is completed with Mother and The son. As a play, it has been incredibly successful and has served its performers as well as Zeller Numerous awards. Will you repeat the success with the film awards?
Source: Sony Pictures
4 Olivia Colman
When you have a giant on the screen of the caliber of Anthony Hopkins it’s hard to find a pair to keep up with you. However, this is not a problem for The Father, who joins the actor with Olivia Colman, an impressive talent who would not be surprised to once again win an award from the Academia to your house. Colman, with his interpretation of Anne, gives the film the right emotion and becomes that character with whom it is very difficult not to feel identified and suffer from the impossible decisions that must be faced.
Source: Sony Pictures
5 A scenic maze
The entire film takes place within an apartment that is, at the same time, the multiple spaces it occupies. Anthony during his life and, also, the labyrinth in which he feels trapped due to the degeneration of his mind. Its nooks and crannies, its changes in furniture, its many doors that open and close serve to show us how, little by little, the character is losing control of everything that surrounds him. The camera, which follows him through those corridors and those turns of corners, makes us also feel that despair and that confinement, that oppression and that fear that he feels Anthony.
Source: Sony Pictures
6 Ludovico Einaudi’s score
One of the joys of Anthony, the protagonist of The FatherIt is listening to classical music and it will be this style that will accompany us throughout the film. The score from the movie, what brings wonderful drama to every scene, was in charge of Ludovico Einaudi, who, curiously, also handled the music of another nominee for this year’s awards: Nomadland.
Source: Sony Pictures
We would like to give thanks to the author of this article for this remarkable content
";}s:7:"summary";s:654:"The awards Oscar They are getting closer and closer and it is time to see all the nominees. If you still do not decide to see The Father, the directorial debut of the French playwright Florian Zeller that explores old age and the advances of senile dementia, below we will give you 7 reasons for ... Read more";s:12:"atom_content";s:8607:"
The awards Oscar They are getting closer and closer and it is time to see all the nominees. If you still do not decide to see The Father, the directorial debut of the French playwright Florian Zeller that explores old age and the advances of senile dementia, below we will give you 7 reasons for you to do so.
1 Anthony Hopkins
The Father gives us what is, perhaps, the best performance of Anthony Hopkins throughout his career And, the truth is, to say that when we talk about an actor of the caliber of Hopkins, its alot. And yet it is not an exaggeration. Hopkinsmanages to show us the confusion, terror, frustration and pain of this man who begins to lose control of his own mind with great sensitivity and mastery. Truly unmissable and completely deserved his nomination for Best Actor at the awards of the Academia.
Credit: Sony Pictures
2 Senile dementia from another perspective
The wonder of The Father is that, for about two hours, it puts us in the confused mind of Anthony, this man who suffers from senile dementia and, from there, we will perceive reality. It is a different approach, which shakes the viewer with the ups and downs of the memory of Anthony, confusing him and making him empathize with the character.
Source: Sony Pictures
3 Theatrical origin
The Father has its origins in the theater, since the film is an adaptation of the work of the same director, Florian Zeller, which is part of the family trilogy that is completed with Mother and The son. As a play, it has been incredibly successful and has served its performers as well as Zeller Numerous awards. Will you repeat the success with the film awards?
Source: Sony Pictures
4 Olivia Colman
When you have a giant on the screen of the caliber of Anthony Hopkins it’s hard to find a pair to keep up with you. However, this is not a problem for The Father, who joins the actor with Olivia Colman, an impressive talent who would not be surprised to once again win an award from the Academia to your house. Colman, with his interpretation of Anne, gives the film the right emotion and becomes that character with whom it is very difficult not to feel identified and suffer from the impossible decisions that must be faced.
Source: Sony Pictures
5 A scenic maze
The entire film takes place within an apartment that is, at the same time, the multiple spaces it occupies. Anthony during his life and, also, the labyrinth in which he feels trapped due to the degeneration of his mind. Its nooks and crannies, its changes in furniture, its many doors that open and close serve to show us how, little by little, the character is losing control of everything that surrounds him. The camera, which follows him through those corridors and those turns of corners, makes us also feel that despair and that confinement, that oppression and that fear that he feels Anthony.
Source: Sony Pictures
6 Ludovico Einaudi’s score
One of the joys of Anthony, the protagonist of The FatherIt is listening to classical music and it will be this style that will accompany us throughout the film. The score from the movie, what brings wonderful drama to every scene, was in charge of Ludovico Einaudi, who, curiously, also handled the music of another nominee for this year’s awards: Nomadland.
Source: Sony Pictures
We would like to give thanks to the author of this article for this remarkable content
";s:14:"date_timestamp";i:1638566581;}i:3;a:11:{s:5:"title";s:108:"The bridge between food and medicine ? Thinking about healthy food takes on pharmacological traits ? Foodlog";s:4:"link";s:138:"https://wikileaksisdemocracy.org/the-bridge-between-food-and-medicine-thinking-about-healthy-food-takes-on-pharmacological-traits-foodlog/";s:2:"dc";a:1:{s:7:"creator";s:12:"Paula Hooper";}s:7:"pubdate";s:31:"Fri, 03 Dec 2021 21:21:55 +0000";s:8:"category";s:75:"LifestylebridgeFoodFoodloghealthymedicinepharmacologicaltakesThinkingTraits";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=5098";s:11:"description";s:800:"Although pharmacology is a fact of life is, little of the research in that scientific discipline penetrates the public media. Yes, when a major pharmaceutical company has developed a promising new drug (a Covid pill, for example), it is highly praised. After all, successful sales start with good marketing. But research articles that appear in ... Read more";s:7:"content";a:1:{s:7:"encoded";s:7546:"
Although pharmacology is a fact of life is, little of the research in that scientific discipline penetrates the public media. Yes, when a major pharmaceutical company has developed a promising new drug (a Covid pill, for example), it is highly praised. After all, successful sales start with good marketing. But research articles that appear in journals such as Pharmacological Reviews The blogs, newspapers, radio and TV usually do not make it.
There is at least one clear reason for this: they are incomprehensible to the uninitiated reader. This also applies to the article ‘Pharmacological Modulation of Immune Responses by Nutritional Components’ that appeared in the above-mentioned journal. The four authors, Marthe T. van Daal, Gert Folkerts, Johan Garssen and Saskia Braber, are affiliated with the Department of Pharmaceutical Sciences of Utrecht University (UU) and conduct fundamental research into the effect of medicines and other substances at the molecular and cellular level.
Use That their work is now once again receiving wider attention, including through a items in Algemeen Dagblad, is not only justified, but in this case also really newsworthy. In a few words: the researchers are building a (biological) logical bridge between pharmacology and nutrition. That bridge was already across the gap between the two disciplines, but strangely enough, it was rarely walked on.
Assistant professor Saskia Braber agrees that the collaboration between the two disciplines was not very close, but sees a convergence. ?It was always two niches. Pharmacologists didn’t look at food. Medical students used to receive only a few hours of nutrition courses in the entire programme, I recently heard. At the University of Wageningen you have a nutrition department and we have pharmacy in Utrecht, but it is only in recent years that we are working together more and more.?
Research into how certain substances, medicines or foods, have an effect on a cellular level has recently become a lot more accurate
Collaboration between different disciplines is essential. This is organized, for example, on the so-called research hub Future Food Utrecht, the initiative of Utrecht University that as mission statement has: ‘Planetary Health: how do we future-proof our food system?’ In addition, the university also participates in a knowledge center in the field of carbohydrates, the Carbohydrate Competence Center, a private-public partnership with, among others, the universities of Groningen and Wageningen and various companies.
receptors There is a reason for the convergence between the disciplines. Research into how certain substances, medicines or foods, have an effect on a cellular level has recently become a lot more accurate. In their article, the Utrecht researchers describe the molecular mechanisms that trigger certain nutrients after they act on receptors in the cells, as it is called. That is very similar to what happens with certain medicines. QEDfood as medicine.
?Notably, there is currently very little clinical and reliable research available on the immunomodulatory effects of food components via receptor signalling,? the researchers write. They reviewed the relevant literature and presented a list of four groups of known ‘pharmacological’ receptors, through which food components and their metabolites also have an effect on the immune system.
That list is ?a tool to better understand the pro-inflammatory and/or anti-inflammatory properties of these dietary components, which could aid efforts to prevent and treat NCDs.? ‘Noncommunicable diseases’ are non-contagious ‘wealth diseases’, such as type 2 diabetes, cardiovascular diseases and some cancers.
Spikes We live in the age of biology, in the age of proteins, in the days of the… spikes, always new molecular nails on the corona mutants. The director of Pfizer Netherlands is happy to meet Beau and his colleagues with a smile to explain how clever they are in his lab. That mechanism, of complex proteins that open the doors to cells, is the work of similar receptors, described by Braber and colleagues in relation to certain food components.
Braber and her team research a large number of foods themselves. ?We look at the effect of substances such as complex carbohydrates, polyunsaturated fatty acids, probiotics and prebiotics, you name it. We look at what effect they have on the cells of the immune system, what effect on the cells in the gut, on pathogenic bacteria and viruses. What diseases can they influence and even prevent? We are conducting research into how we can make the intestinal barrier stronger so that fewer pathogens can pass through. We specialize in that. We test which medicines or nutrients can restore the intestinal wall.?
breast milk In addition to having a prebiotic effect in the gut, some oligosaccharides also act directly on immune cells. That is a fairly new branch of research for us, says Braber. ?We have shown that certain oligosaccharides are not only processed by bacteria, but also act directly on immune cells and cells of the intestinal wall, thereby strengthening the intestinal barrier. We are conducting a study in which we are looking at the effect nutrients have on the lungs, what the interaction is between the gut and the lungs. We are even investigating whether we can administer nutrients with nasal sprays.?
Braber himself studies the oligosaccharides that occur in breast milk. The idea behind this is that they play such an important role in building a child’s immune system that they should also be able to work later in life.
?These sugars can do much more than we think, promote good bacteria, inhibit bad ones and, apart from that, stimulate the immune system. I think there is still a lot to learn about the well-known foods, the sugars, the fatty acids and the proteins in the future. The advantage of collaborating with the business community is that you are working on something that can be produced at a later date and which may come on the market for the benefit of patients.?
We would like to give thanks to the author of this write-up for this incredible content
";}s:7:"summary";s:800:"Although pharmacology is a fact of life is, little of the research in that scientific discipline penetrates the public media. Yes, when a major pharmaceutical company has developed a promising new drug (a Covid pill, for example), it is highly praised. After all, successful sales start with good marketing. But research articles that appear in ... Read more";s:12:"atom_content";s:7546:"
Although pharmacology is a fact of life is, little of the research in that scientific discipline penetrates the public media. Yes, when a major pharmaceutical company has developed a promising new drug (a Covid pill, for example), it is highly praised. After all, successful sales start with good marketing. But research articles that appear in journals such as Pharmacological Reviews The blogs, newspapers, radio and TV usually do not make it.
There is at least one clear reason for this: they are incomprehensible to the uninitiated reader. This also applies to the article ‘Pharmacological Modulation of Immune Responses by Nutritional Components’ that appeared in the above-mentioned journal. The four authors, Marthe T. van Daal, Gert Folkerts, Johan Garssen and Saskia Braber, are affiliated with the Department of Pharmaceutical Sciences of Utrecht University (UU) and conduct fundamental research into the effect of medicines and other substances at the molecular and cellular level.
Use That their work is now once again receiving wider attention, including through a items in Algemeen Dagblad, is not only justified, but in this case also really newsworthy. In a few words: the researchers are building a (biological) logical bridge between pharmacology and nutrition. That bridge was already across the gap between the two disciplines, but strangely enough, it was rarely walked on.
Assistant professor Saskia Braber agrees that the collaboration between the two disciplines was not very close, but sees a convergence. ?It was always two niches. Pharmacologists didn’t look at food. Medical students used to receive only a few hours of nutrition courses in the entire programme, I recently heard. At the University of Wageningen you have a nutrition department and we have pharmacy in Utrecht, but it is only in recent years that we are working together more and more.?
Research into how certain substances, medicines or foods, have an effect on a cellular level has recently become a lot more accurate
Collaboration between different disciplines is essential. This is organized, for example, on the so-called research hub Future Food Utrecht, the initiative of Utrecht University that as mission statement has: ‘Planetary Health: how do we future-proof our food system?’ In addition, the university also participates in a knowledge center in the field of carbohydrates, the Carbohydrate Competence Center, a private-public partnership with, among others, the universities of Groningen and Wageningen and various companies.
receptors There is a reason for the convergence between the disciplines. Research into how certain substances, medicines or foods, have an effect on a cellular level has recently become a lot more accurate. In their article, the Utrecht researchers describe the molecular mechanisms that trigger certain nutrients after they act on receptors in the cells, as it is called. That is very similar to what happens with certain medicines. QEDfood as medicine.
?Notably, there is currently very little clinical and reliable research available on the immunomodulatory effects of food components via receptor signalling,? the researchers write. They reviewed the relevant literature and presented a list of four groups of known ‘pharmacological’ receptors, through which food components and their metabolites also have an effect on the immune system.
That list is ?a tool to better understand the pro-inflammatory and/or anti-inflammatory properties of these dietary components, which could aid efforts to prevent and treat NCDs.? ‘Noncommunicable diseases’ are non-contagious ‘wealth diseases’, such as type 2 diabetes, cardiovascular diseases and some cancers.
Spikes We live in the age of biology, in the age of proteins, in the days of the… spikes, always new molecular nails on the corona mutants. The director of Pfizer Netherlands is happy to meet Beau and his colleagues with a smile to explain how clever they are in his lab. That mechanism, of complex proteins that open the doors to cells, is the work of similar receptors, described by Braber and colleagues in relation to certain food components.
Braber and her team research a large number of foods themselves. ?We look at the effect of substances such as complex carbohydrates, polyunsaturated fatty acids, probiotics and prebiotics, you name it. We look at what effect they have on the cells of the immune system, what effect on the cells in the gut, on pathogenic bacteria and viruses. What diseases can they influence and even prevent? We are conducting research into how we can make the intestinal barrier stronger so that fewer pathogens can pass through. We specialize in that. We test which medicines or nutrients can restore the intestinal wall.?
breast milk In addition to having a prebiotic effect in the gut, some oligosaccharides also act directly on immune cells. That is a fairly new branch of research for us, says Braber. ?We have shown that certain oligosaccharides are not only processed by bacteria, but also act directly on immune cells and cells of the intestinal wall, thereby strengthening the intestinal barrier. We are conducting a study in which we are looking at the effect nutrients have on the lungs, what the interaction is between the gut and the lungs. We are even investigating whether we can administer nutrients with nasal sprays.?
Braber himself studies the oligosaccharides that occur in breast milk. The idea behind this is that they play such an important role in building a child’s immune system that they should also be able to work later in life.
?These sugars can do much more than we think, promote good bacteria, inhibit bad ones and, apart from that, stimulate the immune system. I think there is still a lot to learn about the well-known foods, the sugars, the fatty acids and the proteins in the future. The advantage of collaborating with the business community is that you are working on something that can be produced at a later date and which may come on the market for the benefit of patients.?
We would like to give thanks to the author of this write-up for this incredible content
";s:14:"date_timestamp";i:1638566515;}i:4;a:11:{s:5:"title";s:68:"Gene-editing used to create single sex mice litters, 100% efficiency";s:4:"link";s:100:"https://wikileaksisdemocracy.org/gene-editing-used-to-create-single-sex-mice-litters-100-efficiency/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Fri, 03 Dec 2021 21:18:07 +0000";s:8:"category";s:65:"Health And SciencecreateefficiencyGeneeditinglittersmicesexSingle";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=5093";s:11:"description";s:741:"Journal Reference: Charlotte Douglas, Valdone Maciulyte, Jasmin Zohren, Daniel M. Snell, Shantha K. Mahadevaiah, Obah A. Ojarikre, Peter J. I. Ellis, James M. A. Turner. CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-27227-2 This proof of principle study, published in Nature Communications today (Friday 3rd December), ... Read more";s:7:"content";a:1:{s:7:"encoded";s:5945:"
Journal Reference:
Charlotte Douglas, Valdone Maciulyte, Jasmin Zohren, Daniel M. Snell, Shantha K. Mahadevaiah, Obah A. Ojarikre, Peter J. I. Ellis, James M. A. Turner. CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-27227-2
This proof of principle study, published in Nature Communications today (Friday 3rd December), demonstrates how the technology could be used to improve animal welfare in scientific research and perhaps also agriculture.
In scientific research and also farming, there is often a need for either male or female animals. For example, laboratory research into male or female reproduction requires only animals of the sex being studied. And in farming, only female animals are required for egg production and in dairy herds. This means it is common practice for animals of the unrequired sex to be culled after birth.
The researchers? new method uses a two-part genetic system to inactivate embryos shortly after fertilisation, allowing only the desired sex to develop. Such a genetically-based method to control the sex of offspring could drastically reduce culling in both industries.
The embryo selection is based on the fact that there are two elements of CRISPR-Cas9 ? the Cas9 enzyme that cuts the DNA, allowing scientists to alter specific regions, and the guide RNA which carries the Cas9 to the right location on the genome. The team placed one element of the system on the father?s X or Y chromosome, meaning that it will only be inherited by female or male embryos respectively. The other element is contributed by the mother, and is inherited by all embryos.
They targeted the Top1 gene, which is essential to DNA replication and repair. When an embryo formed from a sperm and egg, each containing one half of CRISPR-Cas9, the gene-editing was triggered in the embryo and it was not able to develop beyond a very early stage of around 16 to 32 cells.
Using this method, the researchers were able to control, with 100% effect, the sex of a litter. To produce a male-only litter, the researchers edited the father?s X chromosome, meaning only females inherited the deleterious mutation, and for a female-only litter, they edited the Y chromosome.
Surprisingly, the method did not lead to a 50% decrease in the number of offspring produced, rather the litter sizes were between 61% ? 72% of the control litters. The researchers suggest this is because animals such as mice produce more eggs than required during each ovarian cycle, allowing for a proportion of them to be lost during early development without reducing litter size. This means that in situations where one sex is needed, fewer breeding animals will be required in order to produce the same number of the desired sex of offspring.
As the Top1 gene is well conserved across mammals, these results may also be applicable to other animals.
Charlotte Douglas, first author and former PhD student and postdoctoral scientist at the Crick, says: ?This method works as we split the genome editing process in half, between a male and female, and it is only when the two halves meet in an embryo through breeding, that it is activated. Embryos with both halves cannot develop beyond very early cell stages.
?We?ve also shown this process works successfully in different combinations ? introducing either the Cas9 or the guide RNA elements on to the mother?s or father?s chromosomes.?
As the offspring which survive only contain half of the CRISPR-Cas9 elements within their genome, this acts as a control preventing the sex-selection being passed down to further generations, unless they are selectively bred with an individual of the opposite sex containing the other half. This is different to genetic engineering through ?gene-drive? methods, which seek to spread a genetic mutation widely amongst a population.
There are also no harmful effects of the gene edit in the surviving offspring.
James Turner, author and group leader of the Sex Chromosome Biology Laboratory at the Crick says: ?This work could have immediate and valuable impact in scientific laboratories, as we?ve shown how it is safe and effective in mice, a common mammal used in medical and scientific research. While a lot of research needs both sexes, there are areas of study where only one is needed. For example, when studying the reproductive system, sex-specific diseases, or certain hormones.?
Peter Ellis, author and senior lecturer in molecular genetics and reproduction at University of Kent, says: ?The implications of this work are potentially far-reaching when it comes to improving animal welfare, but should be considered at ethical and regulatory levels.
?In particular, before any potential use in agriculture, there would need to be extensive public conversation and debate, as well as changes to legislation. On the scientific side, there is also much work to be done over a number of years. Further research is needed, first to develop the particular gene editing toolkits for different species, and then to check they are safe and effective.?
We would like to thank the author of this short article for this incredible content
";}s:7:"summary";s:741:"Journal Reference: Charlotte Douglas, Valdone Maciulyte, Jasmin Zohren, Daniel M. Snell, Shantha K. Mahadevaiah, Obah A. Ojarikre, Peter J. I. Ellis, James M. A. Turner. CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-27227-2 This proof of principle study, published in Nature Communications today (Friday 3rd December), ... Read more";s:12:"atom_content";s:5945:"
Journal Reference:
Charlotte Douglas, Valdone Maciulyte, Jasmin Zohren, Daniel M. Snell, Shantha K. Mahadevaiah, Obah A. Ojarikre, Peter J. I. Ellis, James M. A. Turner. CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-27227-2
This proof of principle study, published in Nature Communications today (Friday 3rd December), demonstrates how the technology could be used to improve animal welfare in scientific research and perhaps also agriculture.
In scientific research and also farming, there is often a need for either male or female animals. For example, laboratory research into male or female reproduction requires only animals of the sex being studied. And in farming, only female animals are required for egg production and in dairy herds. This means it is common practice for animals of the unrequired sex to be culled after birth.
The researchers? new method uses a two-part genetic system to inactivate embryos shortly after fertilisation, allowing only the desired sex to develop. Such a genetically-based method to control the sex of offspring could drastically reduce culling in both industries.
The embryo selection is based on the fact that there are two elements of CRISPR-Cas9 ? the Cas9 enzyme that cuts the DNA, allowing scientists to alter specific regions, and the guide RNA which carries the Cas9 to the right location on the genome. The team placed one element of the system on the father?s X or Y chromosome, meaning that it will only be inherited by female or male embryos respectively. The other element is contributed by the mother, and is inherited by all embryos.
They targeted the Top1 gene, which is essential to DNA replication and repair. When an embryo formed from a sperm and egg, each containing one half of CRISPR-Cas9, the gene-editing was triggered in the embryo and it was not able to develop beyond a very early stage of around 16 to 32 cells.
Using this method, the researchers were able to control, with 100% effect, the sex of a litter. To produce a male-only litter, the researchers edited the father?s X chromosome, meaning only females inherited the deleterious mutation, and for a female-only litter, they edited the Y chromosome.
Surprisingly, the method did not lead to a 50% decrease in the number of offspring produced, rather the litter sizes were between 61% ? 72% of the control litters. The researchers suggest this is because animals such as mice produce more eggs than required during each ovarian cycle, allowing for a proportion of them to be lost during early development without reducing litter size. This means that in situations where one sex is needed, fewer breeding animals will be required in order to produce the same number of the desired sex of offspring.
As the Top1 gene is well conserved across mammals, these results may also be applicable to other animals.
Charlotte Douglas, first author and former PhD student and postdoctoral scientist at the Crick, says: ?This method works as we split the genome editing process in half, between a male and female, and it is only when the two halves meet in an embryo through breeding, that it is activated. Embryos with both halves cannot develop beyond very early cell stages.
?We?ve also shown this process works successfully in different combinations ? introducing either the Cas9 or the guide RNA elements on to the mother?s or father?s chromosomes.?
As the offspring which survive only contain half of the CRISPR-Cas9 elements within their genome, this acts as a control preventing the sex-selection being passed down to further generations, unless they are selectively bred with an individual of the opposite sex containing the other half. This is different to genetic engineering through ?gene-drive? methods, which seek to spread a genetic mutation widely amongst a population.
There are also no harmful effects of the gene edit in the surviving offspring.
James Turner, author and group leader of the Sex Chromosome Biology Laboratory at the Crick says: ?This work could have immediate and valuable impact in scientific laboratories, as we?ve shown how it is safe and effective in mice, a common mammal used in medical and scientific research. While a lot of research needs both sexes, there are areas of study where only one is needed. For example, when studying the reproductive system, sex-specific diseases, or certain hormones.?
Peter Ellis, author and senior lecturer in molecular genetics and reproduction at University of Kent, says: ?The implications of this work are potentially far-reaching when it comes to improving animal welfare, but should be considered at ethical and regulatory levels.
?In particular, before any potential use in agriculture, there would need to be extensive public conversation and debate, as well as changes to legislation. On the scientific side, there is also much work to be done over a number of years. Further research is needed, first to develop the particular gene editing toolkits for different species, and then to check they are safe and effective.?
We would like to thank the author of this short article for this incredible content
";s:14:"date_timestamp";i:1638566287;}i:5;a:11:{s:5:"title";s:67:"Anthony Hopkins: ?Life is absurd, we take everything too seriously?";s:4:"link";s:99:"https://wikileaksisdemocracy.org/anthony-hopkins-life-is-absurd-we-take-everything-too-seriously-5/";s:2:"dc";a:1:{s:7:"creator";s:12:"Sally Scully";}s:7:"pubdate";s:31:"Fri, 03 Dec 2021 21:16:30 +0000";s:8:"category";s:33:"CelebrityabsurdAnthonyHopkinsLife";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=5087";s:11:"description";s:689:"Thirty years after winning his first Oscar for one of the most iconic characters in film history, the Hannibal Lecter of “The Silence of the Lambs”, Anthony Hopkins could repeat his statuette with “The Father” in a radically opposite and fragile register of a man suffering from senile dementia. In real life, the Welsh-born actor ... Read more";s:7:"content";a:1:{s:7:"encoded";s:6192:"
Thirty years after winning his first Oscar for one of the most iconic characters in film history, the Hannibal Lecter of “The Silence of the Lambs”, Anthony Hopkins could repeat his statuette with “The Father” in a radically opposite and fragile register of a man suffering from senile dementia.
In real life, the Welsh-born actor displays a friendly demeanor and excellent humor that contrasts with the turbulence of both characters: he tells anecdotes, recites poems and shoves his audience in his pocket, including Olivia Colman, his co-star and daughter in fiction, turned into one more listener in a telematic interview with various international media.
“Life is absurd, it’s ridiculous, we take everything too seriously,” says 83-year-old Hopkins. “I try to cultivate the art of indifference, not in a sense of coldness, but the things that a few years ago I thought important now do not seem so to me, we are all going to die and that is the blackest and funniest joke.”
“The father”, premiered in Spain on December 23 and now expanding its presence in theaters for the Oscars – whose nominations are announced today – is the debut of the French writer and playwright Florian Zeller. His great discovery is that he places the viewer in the mind of the patient, makes him experience his confusion, his anger, his fear.
Hopkins remembers that when he read the script he felt something similar to what happened to him with “The Silence of the Lambs.” He knew instantly that he wanted to. “I met with Florian and said yes, but I had the filming of ‘The Two Papas’ pending (with Jonathan Pryce and the direction of Fernando Meirelles) and I was really worried that they would not wait for me, but they did,” he says. .
In the case of Hannibal Lecter, Hopkins recalls that when he began to read the script, he asked his agent if the deal was already closed. “He said no and I didn’t want to read any more until I knew, because he was the best character I could have ever dreamed of.”
He says that to keep his brain active he plays the piano, paints or memorizes poems by Dylan Thomas, but when it comes to talking about his merits as an actor or uncovering the secrets of some of the most legendary scenes of his career, he insists on subtracting importance.
“Acting does not require being a genius or a great intellectual effort, there will be people who are interested in making it look like that, but no,” he defends.
“In ‘The Silence of the Lambs’ Jodie came with a coffee in hand, we would stare at each other through a glass wall and blurt out the text. That’s it. We still meet sometimes to eat together and talk about how funny this is way of making a living. “
According to Zeller, Hopkins is an instinctive actor. “I am simply old”, replies the interpreter, “I have been active for many years so I know some tricks; the Stanislavski method is wonderful and I practiced it when I was young, but now it is more common sense than anything else”.
“When you get to 83, I don’t know if you’re smarter or stupider, but you certainly don’t waste your time thinking too much about yourself,” he adds. “When it comes to acting, I just do it and that’s it, and with an actress like Olivia, a wonderful director and a good script like this one, that’s the most important thing,” he adds in reference to “The father.”
However, at another point in the interview he confesses that when they were filming, between takes, he would stand in front of a mirror and repeat to himself: ‘This is just a game, okay? I am not suffering from dementia, I am acting, I am acting. ‘
“You have to be careful with the message that you transfer to your subconscious because it can be believed,” he explains. “I remind my brain of things, when it tells me that my memory is failing or that I am getting older, I say no, that I am still young and strong, and the brain believes it, it really works.”
He also does not practice looking back too much. “My past seems like a dream to me, I feel like I can’t be responsible for anything, I don’t know why I became an actor, I don’t remember, I tend to think that everything has been a solipsism, that my parents never existed, they are only memories” .
His father died more than 40 years ago from heart disease. “He was in the hospital and I knew he was dying, that he was not going to leave, but suddenly you see yourself making strange promises; I told him that when he left I would take him on a car trip from New York to Los Angeles and a few days later I went to see him and he was sitting there with a road map of the United States, so happy. “
“It is painful when you know that they are dying but I suppose the only thing you can do is reassure them and let them know that you are there,” he says.
His mother passed away years later. “My wife Stella was with her and to reassure her she told her that when she got to the other side she would meet her husband again. My mother, who was not very religious, replied: ‘Will it be very expensive?’ He had a great sense of humor at the end. ”
Magdalena Tsanis
We want to say thanks to the writer of this post for this remarkable content
";}s:7:"summary";s:689:"Thirty years after winning his first Oscar for one of the most iconic characters in film history, the Hannibal Lecter of “The Silence of the Lambs”, Anthony Hopkins could repeat his statuette with “The Father” in a radically opposite and fragile register of a man suffering from senile dementia. In real life, the Welsh-born actor ... Read more";s:12:"atom_content";s:6192:"
Thirty years after winning his first Oscar for one of the most iconic characters in film history, the Hannibal Lecter of “The Silence of the Lambs”, Anthony Hopkins could repeat his statuette with “The Father” in a radically opposite and fragile register of a man suffering from senile dementia.
In real life, the Welsh-born actor displays a friendly demeanor and excellent humor that contrasts with the turbulence of both characters: he tells anecdotes, recites poems and shoves his audience in his pocket, including Olivia Colman, his co-star and daughter in fiction, turned into one more listener in a telematic interview with various international media.
“Life is absurd, it’s ridiculous, we take everything too seriously,” says 83-year-old Hopkins. “I try to cultivate the art of indifference, not in a sense of coldness, but the things that a few years ago I thought important now do not seem so to me, we are all going to die and that is the blackest and funniest joke.”
“The father”, premiered in Spain on December 23 and now expanding its presence in theaters for the Oscars – whose nominations are announced today – is the debut of the French writer and playwright Florian Zeller. His great discovery is that he places the viewer in the mind of the patient, makes him experience his confusion, his anger, his fear.
Hopkins remembers that when he read the script he felt something similar to what happened to him with “The Silence of the Lambs.” He knew instantly that he wanted to. “I met with Florian and said yes, but I had the filming of ‘The Two Papas’ pending (with Jonathan Pryce and the direction of Fernando Meirelles) and I was really worried that they would not wait for me, but they did,” he says. .
In the case of Hannibal Lecter, Hopkins recalls that when he began to read the script, he asked his agent if the deal was already closed. “He said no and I didn’t want to read any more until I knew, because he was the best character I could have ever dreamed of.”
He says that to keep his brain active he plays the piano, paints or memorizes poems by Dylan Thomas, but when it comes to talking about his merits as an actor or uncovering the secrets of some of the most legendary scenes of his career, he insists on subtracting importance.
“Acting does not require being a genius or a great intellectual effort, there will be people who are interested in making it look like that, but no,” he defends.
“In ‘The Silence of the Lambs’ Jodie came with a coffee in hand, we would stare at each other through a glass wall and blurt out the text. That’s it. We still meet sometimes to eat together and talk about how funny this is way of making a living. “
According to Zeller, Hopkins is an instinctive actor. “I am simply old”, replies the interpreter, “I have been active for many years so I know some tricks; the Stanislavski method is wonderful and I practiced it when I was young, but now it is more common sense than anything else”.
“When you get to 83, I don’t know if you’re smarter or stupider, but you certainly don’t waste your time thinking too much about yourself,” he adds. “When it comes to acting, I just do it and that’s it, and with an actress like Olivia, a wonderful director and a good script like this one, that’s the most important thing,” he adds in reference to “The father.”
However, at another point in the interview he confesses that when they were filming, between takes, he would stand in front of a mirror and repeat to himself: ‘This is just a game, okay? I am not suffering from dementia, I am acting, I am acting. ‘
“You have to be careful with the message that you transfer to your subconscious because it can be believed,” he explains. “I remind my brain of things, when it tells me that my memory is failing or that I am getting older, I say no, that I am still young and strong, and the brain believes it, it really works.”
He also does not practice looking back too much. “My past seems like a dream to me, I feel like I can’t be responsible for anything, I don’t know why I became an actor, I don’t remember, I tend to think that everything has been a solipsism, that my parents never existed, they are only memories” .
His father died more than 40 years ago from heart disease. “He was in the hospital and I knew he was dying, that he was not going to leave, but suddenly you see yourself making strange promises; I told him that when he left I would take him on a car trip from New York to Los Angeles and a few days later I went to see him and he was sitting there with a road map of the United States, so happy. “
“It is painful when you know that they are dying but I suppose the only thing you can do is reassure them and let them know that you are there,” he says.
His mother passed away years later. “My wife Stella was with her and to reassure her she told her that when she got to the other side she would meet her husband again. My mother, who was not very religious, replied: ‘Will it be very expensive?’ He had a great sense of humor at the end. ”
Magdalena Tsanis
We want to say thanks to the writer of this post for this remarkable content
";s:14:"date_timestamp";i:1638566190;}i:6;a:11:{s:5:"title";s:94:"Mom and Kids Awards 2021, More Exciting with New Categories and Nominations: Okezone Celebrity";s:4:"link";s:126:"https://wikileaksisdemocracy.org/mom-and-kids-awards-2021-more-exciting-with-new-categories-and-nominations-okezone-celebrity/";s:2:"dc";a:1:{s:7:"creator";s:12:"Sally Scully";}s:7:"pubdate";s:31:"Fri, 03 Dec 2021 21:03:40 +0000";s:8:"category";s:63:"ShowsAwardsCategoriesCelebrityExcitingkidsmomNominationsOkezone";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=5081";s:11:"description";s:700:"JAKARTA – MNCTV is proud to again hold an appreciation event for millennial mothers and children, namely Mom & Kids Awards (MAKA) 2021, this award event has been held 6 times by MNCTV since 2015 and still exists today. MAKA 2021 will be broadcast by MNCTV live on December 10, 2021 at 15.30 at MNC ... Read more";s:7:"content";a:1:{s:7:"encoded";s:7597:"
JAKARTA – MNCTV is proud to again hold an appreciation event for millennial mothers and children, namely Mom & Kids Awards (MAKA) 2021, this award event has been held 6 times by MNCTV since 2015 and still exists today. MAKA 2021 will be broadcast by MNCTV live on December 10, 2021 at 15.30 at MNC Studios, West Jakarta.
These nominations were selected based on the idols of Indonesian mothers and children, rating & share performance, as well as various responses from social media.
Also Read:
Tiara Andini Looks Beautiful at the 2020 Mom And Kids Awards
Being an Inspiring Mother, Denada Gets IDR 100 Million Appreciation at the 2020 Mom & Kids Awards
The theme carried by MAKA 2021 is “supermom” which will describe the child’s pride and love for the mother and the role of parents, especially mothers to their children.
A number of well-known artists and children have been nominated, such as these categories that will be able to be voted on via IG and RCTI+ are 9 categories and 2 special categories including ‘the category of favorite animation series’. This nomination is determined based on the featured cartoons that aired on MNCTV in December 2020 ? December 2021, the ‘beloved idol category’ in this nomination is a singer or soap opera star, idolized by Indonesian children and youth, popular and actively appearing on MNCTV. This nomination ‘baby celebrity category’ contains celebrity children aged 1.5 – 3 years who are in the spotlight on social media, have their own social media accounts & are loved by the public because of their cute & adorable behavior.
Then ‘Category of favorite celebrity kids’ This category consists of celebrity children aged 4-7 years who are in the spotlight on television and are favored by the public. The ‘beloved mother-to-be’ category in this category are celebrities who are pregnant with their first child, and are active on social media. The ‘favorite daddy category’ is an award for a father figure among celebrities who are close to their children on social media and television who are able to provide inspiration to improve the quality of the bond between father and son. The ‘favorite family category’ is an award for celebrity family figures who are popular on television and social media and their appearance looks compact, harmonious and inspiring. The ‘mom & baby category’ is an award for new mothers and celebrity babies aged 0 – 1.5 years whose exposure to their closeness with their children on social media and television can inspire them to improve the quality of the bond between mother and child.
Then the ‘favorite mom and kids category’ is an award for celebrity mothers and children aged 4 ? 7 whose exposure to their closeness with their children on social media and television can inspire them to improve the quality of the bond between mother and child. Special categories will also be awarded for the ‘brilliant child’ and ‘super mom’ categories.
There are also many names who are ready to compete at MAKA 2021, here are the MAKA 2021 categories:
1. Favorite Animation Series Category
Alvin And Chipmunks
Backkom
Kiko
Shaun The Sheep
Upin Ipin
Zak Storm
2. Favorite Idol Category
Alifa Lubis
Anneth
Alwi Assegaf
Betrand Peto
Darren Rafid Khairan
Zayyan Sakha
3. Favorite Baby Celebrity Category
Claire Herbowo (Shandy Aulia)1.9 Yr
Gala Sky (Vanessa Angel) 1.7th
Kiano Tiger Wong (Baim Wong) 2 Th
Mikhael Moeis (Sandra Dewi) 2.2
Shaquille (Cut Meyriska) 1.5th
Thania Putri Onsu (Ruben Onsu) 2 Th
4. Favorite Kids Celebrity Category
Throne
Bilqis
The quake
Rafathar
Raphael Moeis
Thalia Son Onsu
5. Dear Mama Candidate Category
Aurel Hermansyah
Ready Kejora
Nadine Chandrawinata
Nathalie Holscher
Nikita Willy
Siti Badriah
6. Dear Daddy Category
Ammar Zoni
Andhika Pratama
Baim Wong
Irwansyah
Rey Mbayang
Ruben Onsu
7. Favorite family category
Anang & Ashanty Family
Andhika & Ussy . Family
Irfan Hakim & Della’s Family
Raffi & Nagita’s Family
Rio Family & Oki Setiana Dewi
Ruben & Sarwendah family.
8. Favorite Mom & Baby Category
Citra Kirana – Athar
Cut Meyriska – Shaquille
Irish Bella ? Airumi
Dinda Hauw – Shaka
Zaskia Gothic ? Arsila
Zaskia Sungkar? Ukasya
9. Dear Mom and Kids
Ashanty ? Throne
Ayu Ting Ting – Bilqis
Nagita ? Rafathar
Sandra Dewi – Raphael Moeis
Sarwendah – Thalia
Ussy ? Sheva
Support your chosen nomination through the RCTI+ application by selecting your favorite nomination on the “Mom and Kids Awards 2021” voting channel and voting via Instagram follow and comment @officialmnctv by typing #VOTEMAKA2021(SPASI) the nomination code in the category photo.
Watch the prestigious award for mothers and children at Mom and Kids 2021 which will be broadcast on Friday, December 10, 2021 at 15.30 WIB at MNC Studios, Kebon Jeruk, West Jakarta, which will be broadcast live on MNCTV. Always in heart.
We would love to give thanks to the author of this article for this awesome web content
";}s:7:"summary";s:700:"JAKARTA – MNCTV is proud to again hold an appreciation event for millennial mothers and children, namely Mom & Kids Awards (MAKA) 2021, this award event has been held 6 times by MNCTV since 2015 and still exists today. MAKA 2021 will be broadcast by MNCTV live on December 10, 2021 at 15.30 at MNC ... Read more";s:12:"atom_content";s:7597:"
JAKARTA – MNCTV is proud to again hold an appreciation event for millennial mothers and children, namely Mom & Kids Awards (MAKA) 2021, this award event has been held 6 times by MNCTV since 2015 and still exists today. MAKA 2021 will be broadcast by MNCTV live on December 10, 2021 at 15.30 at MNC Studios, West Jakarta.
These nominations were selected based on the idols of Indonesian mothers and children, rating & share performance, as well as various responses from social media.
Also Read:
Tiara Andini Looks Beautiful at the 2020 Mom And Kids Awards
Being an Inspiring Mother, Denada Gets IDR 100 Million Appreciation at the 2020 Mom & Kids Awards
The theme carried by MAKA 2021 is “supermom” which will describe the child’s pride and love for the mother and the role of parents, especially mothers to their children.
A number of well-known artists and children have been nominated, such as these categories that will be able to be voted on via IG and RCTI+ are 9 categories and 2 special categories including ‘the category of favorite animation series’. This nomination is determined based on the featured cartoons that aired on MNCTV in December 2020 ? December 2021, the ‘beloved idol category’ in this nomination is a singer or soap opera star, idolized by Indonesian children and youth, popular and actively appearing on MNCTV. This nomination ‘baby celebrity category’ contains celebrity children aged 1.5 – 3 years who are in the spotlight on social media, have their own social media accounts & are loved by the public because of their cute & adorable behavior.
Then ‘Category of favorite celebrity kids’ This category consists of celebrity children aged 4-7 years who are in the spotlight on television and are favored by the public. The ‘beloved mother-to-be’ category in this category are celebrities who are pregnant with their first child, and are active on social media. The ‘favorite daddy category’ is an award for a father figure among celebrities who are close to their children on social media and television who are able to provide inspiration to improve the quality of the bond between father and son. The ‘favorite family category’ is an award for celebrity family figures who are popular on television and social media and their appearance looks compact, harmonious and inspiring. The ‘mom & baby category’ is an award for new mothers and celebrity babies aged 0 – 1.5 years whose exposure to their closeness with their children on social media and television can inspire them to improve the quality of the bond between mother and child.
Then the ‘favorite mom and kids category’ is an award for celebrity mothers and children aged 4 ? 7 whose exposure to their closeness with their children on social media and television can inspire them to improve the quality of the bond between mother and child. Special categories will also be awarded for the ‘brilliant child’ and ‘super mom’ categories.
There are also many names who are ready to compete at MAKA 2021, here are the MAKA 2021 categories:
1. Favorite Animation Series Category
Alvin And Chipmunks
Backkom
Kiko
Shaun The Sheep
Upin Ipin
Zak Storm
2. Favorite Idol Category
Alifa Lubis
Anneth
Alwi Assegaf
Betrand Peto
Darren Rafid Khairan
Zayyan Sakha
3. Favorite Baby Celebrity Category
Claire Herbowo (Shandy Aulia)1.9 Yr
Gala Sky (Vanessa Angel) 1.7th
Kiano Tiger Wong (Baim Wong) 2 Th
Mikhael Moeis (Sandra Dewi) 2.2
Shaquille (Cut Meyriska) 1.5th
Thania Putri Onsu (Ruben Onsu) 2 Th
4. Favorite Kids Celebrity Category
Throne
Bilqis
The quake
Rafathar
Raphael Moeis
Thalia Son Onsu
5. Dear Mama Candidate Category
Aurel Hermansyah
Ready Kejora
Nadine Chandrawinata
Nathalie Holscher
Nikita Willy
Siti Badriah
6. Dear Daddy Category
Ammar Zoni
Andhika Pratama
Baim Wong
Irwansyah
Rey Mbayang
Ruben Onsu
7. Favorite family category
Anang & Ashanty Family
Andhika & Ussy . Family
Irfan Hakim & Della’s Family
Raffi & Nagita’s Family
Rio Family & Oki Setiana Dewi
Ruben & Sarwendah family.
8. Favorite Mom & Baby Category
Citra Kirana – Athar
Cut Meyriska – Shaquille
Irish Bella ? Airumi
Dinda Hauw – Shaka
Zaskia Gothic ? Arsila
Zaskia Sungkar? Ukasya
9. Dear Mom and Kids
Ashanty ? Throne
Ayu Ting Ting – Bilqis
Nagita ? Rafathar
Sandra Dewi – Raphael Moeis
Sarwendah – Thalia
Ussy ? Sheva
Support your chosen nomination through the RCTI+ application by selecting your favorite nomination on the “Mom and Kids Awards 2021” voting channel and voting via Instagram follow and comment @officialmnctv by typing #VOTEMAKA2021(SPASI) the nomination code in the category photo.
Watch the prestigious award for mothers and children at Mom and Kids 2021 which will be broadcast on Friday, December 10, 2021 at 15.30 WIB at MNC Studios, Kebon Jeruk, West Jakarta, which will be broadcast live on MNCTV. Always in heart.
We would love to give thanks to the author of this article for this awesome web content
";s:14:"date_timestamp";i:1638565420;}i:7;a:11:{s:5:"title";s:100:"Watch Vision+ Life Cycle, You Can Donate for People with Mental Health Disorders : Okezone Celebrity";s:4:"link";s:130:"https://wikileaksisdemocracy.org/watch-vision-life-cycle-you-can-donate-for-people-with-mental-health-disorders-okezone-celebrity/";s:2:"dc";a:1:{s:7:"creator";s:11:"David Lonit";}s:7:"pubdate";s:31:"Fri, 03 Dec 2021 20:25:05 +0000";s:8:"category";s:74:"ShowsCelebritycycledisordersDonatehealthLifementalOkezonepeopleVisionwatch";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=5075";s:11:"description";s:774:"JAKARTA – Original series Vision+, Life cycle invite the audience to care about mental health. The original series, which was produced by the collaboration between Vision+ and Being Human, also invites the audience to contribute to helping people with mental disorders or mental health disorders. Collaborating with MNC Peduli, Vision+ and Being Human to raise ... Read more";s:7:"content";a:1:{s:7:"encoded";s:4385:"
JAKARTA – Original series Vision+, Life cycle invite the audience to care about mental health. The original series, which was produced by the collaboration between Vision+ and Being Human, also invites the audience to contribute to helping people with mental disorders or mental health disorders.
Collaborating with MNC Peduli, Vision+ and Being Human to raise funds to support movements related to mental health issues in Indonesia.
Also Read:
Vision+ and Being Human Brings Festival Lifecycle
Jessica Tanoesoedibjo Salutes Life Cycle Raises the Importance of Mental Health
This was revealed by Co-Founder Being Human, Adam A Abednego at the Life Cycle Festival held at the Jakarta Concert Hall, Kebon Sirih, Central Jakarta, Friday (12/3/2021).
“We are also working with MNC Peduli. Because apart from promoting films, we also want to have an impact on society. That’s why we also raise funds to help friends who do have mental disorders or mental disorders,” said Adam at the Life Cycle Festival at the Jakarta Concert Hall, Kebon Sirih, Central Jakarta, Friday.
The viewers of the Life Cycle series, he continued, can help make contributions that will later be given to people who really need it.
“Friends when watching the Life Cycle can help donate a small amount of funds which we will later give to people in need, especially from friends who have mental disorders,” he said.
Meanwhile, Chairwoman MNC Peduli Jessica Tanoesoedibjo feels proud to be collaborating in the production of the original series, Lifecycle. “Through this series, we invite every audience of Daur Hidup to give a helping hand to friends who may be experiencing mental health issues,” said Jessica Tanoesoedibjo who was also present at the Daur Hidup Festival.
As previously reported, the original Life Cycle series itself was just released and aired on December 1, 2021 exclusively on the Vision+ app. In the Life Cycle, there are interesting impressions about the meaning of life through the nine phases of life.
The nine phases of life are set in 9 episodes. Among them are Born, Growing, Growing, Home, Visiting, Moving, Settling, Gathering, and Going Home.
Curious about the stories in the Life Cycle? Watch 9 episodes of the Life Cycle on the Vision+ application for free starting from December 1, 2021. To contribute, you can immediately read more information and donate on the official MNC Peduli website.
We wish to say thanks to the writer of this post for this outstanding content
";}s:7:"summary";s:774:"JAKARTA – Original series Vision+, Life cycle invite the audience to care about mental health. The original series, which was produced by the collaboration between Vision+ and Being Human, also invites the audience to contribute to helping people with mental disorders or mental health disorders. Collaborating with MNC Peduli, Vision+ and Being Human to raise ... Read more";s:12:"atom_content";s:4385:"
JAKARTA – Original series Vision+, Life cycle invite the audience to care about mental health. The original series, which was produced by the collaboration between Vision+ and Being Human, also invites the audience to contribute to helping people with mental disorders or mental health disorders.
Collaborating with MNC Peduli, Vision+ and Being Human to raise funds to support movements related to mental health issues in Indonesia.
Also Read:
Vision+ and Being Human Brings Festival Lifecycle
Jessica Tanoesoedibjo Salutes Life Cycle Raises the Importance of Mental Health
This was revealed by Co-Founder Being Human, Adam A Abednego at the Life Cycle Festival held at the Jakarta Concert Hall, Kebon Sirih, Central Jakarta, Friday (12/3/2021).
“We are also working with MNC Peduli. Because apart from promoting films, we also want to have an impact on society. That’s why we also raise funds to help friends who do have mental disorders or mental disorders,” said Adam at the Life Cycle Festival at the Jakarta Concert Hall, Kebon Sirih, Central Jakarta, Friday.
The viewers of the Life Cycle series, he continued, can help make contributions that will later be given to people who really need it.
“Friends when watching the Life Cycle can help donate a small amount of funds which we will later give to people in need, especially from friends who have mental disorders,” he said.
Meanwhile, Chairwoman MNC Peduli Jessica Tanoesoedibjo feels proud to be collaborating in the production of the original series, Lifecycle. “Through this series, we invite every audience of Daur Hidup to give a helping hand to friends who may be experiencing mental health issues,” said Jessica Tanoesoedibjo who was also present at the Daur Hidup Festival.
As previously reported, the original Life Cycle series itself was just released and aired on December 1, 2021 exclusively on the Vision+ app. In the Life Cycle, there are interesting impressions about the meaning of life through the nine phases of life.
The nine phases of life are set in 9 episodes. Among them are Born, Growing, Growing, Home, Visiting, Moving, Settling, Gathering, and Going Home.
Curious about the stories in the Life Cycle? Watch 9 episodes of the Life Cycle on the Vision+ application for free starting from December 1, 2021. To contribute, you can immediately read more information and donate on the official MNC Peduli website.
We wish to say thanks to the writer of this post for this outstanding content
";s:14:"date_timestamp";i:1638563105;}i:8;a:11:{s:5:"title";s:58:"Machine learning helps mathematicians make new connections";s:4:"link";s:92:"https://wikileaksisdemocracy.org/machine-learning-helps-mathematicians-make-new-connections/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Fri, 03 Dec 2021 20:01:18 +0000";s:8:"category";s:63:"Health And ScienceconnectionshelpslearningMachinemathematicians";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=5070";s:11:"description";s:703:"Journal Reference: Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x While computers have long been used to generate data for ... Read more";s:7:"content";a:1:{s:7:"encoded";s:3738:"
Journal Reference:
Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x
While computers have long been used to generate data for mathematicians, the task of identifying interesting patterns has relied mainly on the intuition of the mathematicians themselves. However, it?s now possible to generate more data than any mathematician can reasonably expect to study in a lifetime. Which is where machine learning comes in.
A paper, published today in Nature, describes how DeepMind was set the task of discerning patterns and connections in the fields of knot theory and representation theory. To the surprise of the mathematicians, new connections were suggested; the mathematicians were then able to examine these connections and prove the conjecture suggested by the AI. These results suggest that machine learning can complement mathematical research, guiding intuition about a problem.
Using the patterns identified by machine learning, mathematicians from the University of Oxford discovered a surprising connection between algebraic and geometric invariants of knots, establishing a completely new theorem in the field. The University of Sydney, meanwhile, used the connections made by the AI to bring them close to proving an old conjecture about Kazhdan-Lusztig polynomials, which has been unsolved for 40 years.
Professor Andras Juhasz, of the Mathematical Institute at the University of Oxford and co-author on the paper, said: ?Pure mathematicians work by formulating conjectures and proving these, resulting in theorems. But where do the conjectures come from?
?We have demonstrated that, when guided by mathematical intuition, machine learning provides a powerful framework that can uncover interesting and provable conjectures in areas where a large amount of data is available, or where the objects are too large to study with classical methods.?
Professor Marc Lackeby, of the Mathematical Institute at the University of Oxford and co-author, said: ?It has been fascinating to use machine learning to discover new and unexpected connections between different areas of mathematics. I believe that the work that we have done in Oxford and in Sydney in collaboration with DeepMind demonstrates that machine learning can be a genuinely useful tool in mathematical research.?
Professor Geordie Williamson, Professor of Mathematics at the University of Sydney and director of the Sydney Mathematical Research Institute and co-author, said: ?AI is an extraordinary tool. This work is one of the first times it has demonstrated its usefulness for pure mathematicians, like me.
?Intuition can take us a long way, but AI can help us find connections the human mind might not always easily spot.?
We would like to say thanks to the writer of this article for this amazing material
";}s:7:"summary";s:703:"Journal Reference: Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x While computers have long been used to generate data for ... Read more";s:12:"atom_content";s:3738:"
Journal Reference:
Alex Davies, Petar Veli?kovi?, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Toma?ev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis, Pushmeet Kohli. Advancing mathematics by guiding human intuition with AI. Nature, 2021; 600 (7887): 70 DOI: 10.1038/s41586-021-04086-x
While computers have long been used to generate data for mathematicians, the task of identifying interesting patterns has relied mainly on the intuition of the mathematicians themselves. However, it?s now possible to generate more data than any mathematician can reasonably expect to study in a lifetime. Which is where machine learning comes in.
A paper, published today in Nature, describes how DeepMind was set the task of discerning patterns and connections in the fields of knot theory and representation theory. To the surprise of the mathematicians, new connections were suggested; the mathematicians were then able to examine these connections and prove the conjecture suggested by the AI. These results suggest that machine learning can complement mathematical research, guiding intuition about a problem.
Using the patterns identified by machine learning, mathematicians from the University of Oxford discovered a surprising connection between algebraic and geometric invariants of knots, establishing a completely new theorem in the field. The University of Sydney, meanwhile, used the connections made by the AI to bring them close to proving an old conjecture about Kazhdan-Lusztig polynomials, which has been unsolved for 40 years.
Professor Andras Juhasz, of the Mathematical Institute at the University of Oxford and co-author on the paper, said: ?Pure mathematicians work by formulating conjectures and proving these, resulting in theorems. But where do the conjectures come from?
?We have demonstrated that, when guided by mathematical intuition, machine learning provides a powerful framework that can uncover interesting and provable conjectures in areas where a large amount of data is available, or where the objects are too large to study with classical methods.?
Professor Marc Lackeby, of the Mathematical Institute at the University of Oxford and co-author, said: ?It has been fascinating to use machine learning to discover new and unexpected connections between different areas of mathematics. I believe that the work that we have done in Oxford and in Sydney in collaboration with DeepMind demonstrates that machine learning can be a genuinely useful tool in mathematical research.?
Professor Geordie Williamson, Professor of Mathematics at the University of Sydney and director of the Sydney Mathematical Research Institute and co-author, said: ?AI is an extraordinary tool. This work is one of the first times it has demonstrated its usefulness for pure mathematicians, like me.
?Intuition can take us a long way, but AI can help us find connections the human mind might not always easily spot.?
We would like to say thanks to the writer of this article for this amazing material
";s:14:"date_timestamp";i:1638561678;}i:9;a:11:{s:5:"title";s:43:"Unlocking the cause of UTI-induced delirium";s:4:"link";s:77:"https://wikileaksisdemocracy.org/unlocking-the-cause-of-uti-induced-delirium/";s:2:"dc";a:1:{s:7:"creator";s:12:"Tony Grantly";}s:7:"pubdate";s:31:"Fri, 03 Dec 2021 18:44:19 +0000";s:8:"category";s:45:"Health And SciencedeliriumUnlockingUTIinduced";s:4:"guid";s:40:"https://wikileaksisdemocracy.org/?p=5065";s:11:"description";s:661:"Journal Reference: Mohammad Harun Rashid, Nicklaus A. Sparrow, Faizan Anwar, Gena Guidry, Ambart E. Covarrubias, Haoming Pang, Chandrakumar Bogguri, S. Ananth Karumanchi, Shouri Lahiri. Interleukin-6 mediates delirium-like phenotypes in a murine model of urinary tract infection. Journal of Neuroinflammation, 2021; 18 (1) DOI: 10.1186/s12974-021-02304-x Older women are among the most susceptible to developing UTIs, an ... Read more";s:7:"content";a:1:{s:7:"encoded";s:5087:"
Journal Reference:
Mohammad Harun Rashid, Nicklaus A. Sparrow, Faizan Anwar, Gena Guidry, Ambart E. Covarrubias, Haoming Pang, Chandrakumar Bogguri, S. Ananth Karumanchi, Shouri Lahiri. Interleukin-6 mediates delirium-like phenotypes in a murine model of urinary tract infection. Journal of Neuroinflammation, 2021; 18 (1) DOI: 10.1186/s12974-021-02304-x
Older women are among the most susceptible to developing UTIs, an infection of the bladder and urethra that causes urinary urgency and pain. UTIs also can cause delirium in older people, resulting in a sharp decline in mental abilities that triggers disoriented thinking.
?Up to one-third of elderly patients hospitalized with UTIs can experience some degree of confusion and reduced awareness of their surroundings,? said Shouri Lahiri, MD, director of the Neurosciences Critical Care Unit and Neurocritical Care Research at Cedars-Sinai and senior author of the study. ?Delirium affects millions of patients a year in the U.S., contributing to longer hospital stays, long-term cognitive problems and increased mortality. Delirium can be a tipping point from which patients never fully recover. This is well established. What is less well established is why this is happening.?
To better understand the specific biological mechanisms behind UTI-associated delirium, Lahiri and colleagues observed laboratory mice with and without UTIs in specially designed mazes. In an arena where the animals could move about freely, uninfected mice spent more time in the center of the chamber. Those with UTIs huddled in the periphery, suggesting they had higher levels of anxiety, a common symptom of delirium.
In a Y-shaped maze with three arms to explore, uninfected mice tended to explore all three arms, while mice with UTIs kept returning to the same one, suggesting a lapse in short-term memory, another feature of delirium.
The investigators also observed structural changes in the brains of mice with UTIs.
In a previous study led by Lahiri, published in February in the American Journal of Respiratory Cell and Molecular Biology, investigators found a connection between ventilator-induced lung injury and delirium. Lahiri and colleagues theorized that in both cases this was because of the reaction of IL-6, which helps regulate immune response, to the lung injury or the UTI.
?Occasionally, when the response of IL-6 is excessive, our research indicates that there can be brain injury,? Lahiri said. ?IL-6 induces changes within the neurons that our studies connected with delirium-like behavior. This is the first time this type of structural and functional change has been demonstrated. We?ve now shown two distinct models of this connection, one non-infectious and one infectious.?
In the current study, when investigators treated some of the infected mice with antibodies that blocked the effects of IL-6, the delirium-like behavior of those animals resolved. ?Treatment with anti-IL-6 antibody in the UTI group normalized all the brain changes, both structural and functional,? Lahiri said. ?A wealth of studies have shown a link between IL-6 and delirium, but only this study and our previous study have shown that IL-6 may play a direct pathological role in delirium.?
If symptoms are treated early, he added, full recovery is possible, and the next step is to design clinical trials with anti-IL-6 antibodies as a treatment for patients with UTI-induced delirium.
?Dr. Lahiri and his team have built a research framework with implications far beyond this study,? said Nancy Sicotte, MD, chair of the Department of Neurology who holds the Women?s Guild Distinguished Chair in Neurology at Cedars-Sinai. ?Building on these efforts could improve outcomes for many of our patients.?
Lahiri believes the model he and co-investigators created could be used to study delirium in other conditions associated with increased incidence of UTI. These include those with pre-existing neurologic disorders like Alzheimer?s disease, Parkinson?s disease, stroke and multiple sclerosis where delirium can be hard to distinguish from the underlying disease but is important to treat.
?A huge population stands to benefit from these investigations,? he said. ?We?re looking to apply this model to these other systemic disease conditions and states where the brain dysfunction caused is potentially reversible.?
We would love to give thanks to the author of this article for this remarkable content
";}s:7:"summary";s:661:"Journal Reference: Mohammad Harun Rashid, Nicklaus A. Sparrow, Faizan Anwar, Gena Guidry, Ambart E. Covarrubias, Haoming Pang, Chandrakumar Bogguri, S. Ananth Karumanchi, Shouri Lahiri. Interleukin-6 mediates delirium-like phenotypes in a murine model of urinary tract infection. Journal of Neuroinflammation, 2021; 18 (1) DOI: 10.1186/s12974-021-02304-x Older women are among the most susceptible to developing UTIs, an ... Read more";s:12:"atom_content";s:5087:"
Journal Reference:
Mohammad Harun Rashid, Nicklaus A. Sparrow, Faizan Anwar, Gena Guidry, Ambart E. Covarrubias, Haoming Pang, Chandrakumar Bogguri, S. Ananth Karumanchi, Shouri Lahiri. Interleukin-6 mediates delirium-like phenotypes in a murine model of urinary tract infection. Journal of Neuroinflammation, 2021; 18 (1) DOI: 10.1186/s12974-021-02304-x
Older women are among the most susceptible to developing UTIs, an infection of the bladder and urethra that causes urinary urgency and pain. UTIs also can cause delirium in older people, resulting in a sharp decline in mental abilities that triggers disoriented thinking.
?Up to one-third of elderly patients hospitalized with UTIs can experience some degree of confusion and reduced awareness of their surroundings,? said Shouri Lahiri, MD, director of the Neurosciences Critical Care Unit and Neurocritical Care Research at Cedars-Sinai and senior author of the study. ?Delirium affects millions of patients a year in the U.S., contributing to longer hospital stays, long-term cognitive problems and increased mortality. Delirium can be a tipping point from which patients never fully recover. This is well established. What is less well established is why this is happening.?
To better understand the specific biological mechanisms behind UTI-associated delirium, Lahiri and colleagues observed laboratory mice with and without UTIs in specially designed mazes. In an arena where the animals could move about freely, uninfected mice spent more time in the center of the chamber. Those with UTIs huddled in the periphery, suggesting they had higher levels of anxiety, a common symptom of delirium.
In a Y-shaped maze with three arms to explore, uninfected mice tended to explore all three arms, while mice with UTIs kept returning to the same one, suggesting a lapse in short-term memory, another feature of delirium.
The investigators also observed structural changes in the brains of mice with UTIs.
In a previous study led by Lahiri, published in February in the American Journal of Respiratory Cell and Molecular Biology, investigators found a connection between ventilator-induced lung injury and delirium. Lahiri and colleagues theorized that in both cases this was because of the reaction of IL-6, which helps regulate immune response, to the lung injury or the UTI.
?Occasionally, when the response of IL-6 is excessive, our research indicates that there can be brain injury,? Lahiri said. ?IL-6 induces changes within the neurons that our studies connected with delirium-like behavior. This is the first time this type of structural and functional change has been demonstrated. We?ve now shown two distinct models of this connection, one non-infectious and one infectious.?
In the current study, when investigators treated some of the infected mice with antibodies that blocked the effects of IL-6, the delirium-like behavior of those animals resolved. ?Treatment with anti-IL-6 antibody in the UTI group normalized all the brain changes, both structural and functional,? Lahiri said. ?A wealth of studies have shown a link between IL-6 and delirium, but only this study and our previous study have shown that IL-6 may play a direct pathological role in delirium.?
If symptoms are treated early, he added, full recovery is possible, and the next step is to design clinical trials with anti-IL-6 antibodies as a treatment for patients with UTI-induced delirium.
?Dr. Lahiri and his team have built a research framework with implications far beyond this study,? said Nancy Sicotte, MD, chair of the Department of Neurology who holds the Women?s Guild Distinguished Chair in Neurology at Cedars-Sinai. ?Building on these efforts could improve outcomes for many of our patients.?
Lahiri believes the model he and co-investigators created could be used to study delirium in other conditions associated with increased incidence of UTI. These include those with pre-existing neurologic disorders like Alzheimer?s disease, Parkinson?s disease, stroke and multiple sclerosis where delirium can be hard to distinguish from the underlying disease but is important to treat.
?A huge population stands to benefit from these investigations,? he said. ?We?re looking to apply this model to these other systemic disease conditions and states where the brain dysfunction caused is potentially reversible.?
We would love to give thanks to the author of this article for this remarkable content
